Speed Racer
Senior Member
Registered: Apr 2003
Location: Napa, CA
Posts: 132 |
Freddy, a Google search for hydrogen peroxide and healing produced similar results from different medical sites.
I'd enjoy riding with you here in Napa
Howard
A strong solution of hydrogen peroxide has been historically used clinically to disinfect wounds. While such an approach may be effective in disinfecting, hydrogen peroxide at that strength may hurt newborn regenerating tissue. The study showed that too much hydrogen peroxide can be damaging to a wound.
Hydrogen peroxide is less used now as a debriding agent than in the past. When hydrogen peroxide is applied to a wound it combines with catalase produced in the tissues and decomposes into oxygen and water, producing effervescence (Potter and Perry, 1993). The rationale was that this helps to loosen materials that might hinder wound recovery and enables them to be washed off more readily. Six-percent w/v hydrogen peroxide (known as ' 20 volume' solution) liberates twenty times its own volume of oxygen upon decomposition (Thomas, 1990a), and is generally diluted 1 in 3 for the irrigation of wounds. The release of oxygen also kills some anaerobic bacteria such as the tetanus bacillus or Escherichia coli that might otherwise infect the wound. This anti-microbial action of hydrogen peroxide can be amplified 100-fold by the addition of L-cysteine (Berglin et al, 1982).
The problem with hydrogen peroxide and some other traditional debriding agents is that they also damage the healthy cells (keratinocytes and fibroblasts) that are needed for wound healing and inhibit their necessary migration into the damaged area (Tatnall, Leigh, and Gibson, 1990; Tatnall, Leigh, and Gibson, 1991; O'Toole, Goel, and Woodley, 1996). In current practice the emphasis has moved away from the use of cytotoxic materials to those which promote healing, including the use of natural signalling molecules such as platelet-derived growth factor (Higgins and Ashry, 1995). In the British National Formulary (1996) hydrogen peroxide is now listed under "Astringents, oxidisers and dyes", and not as a desloughing agent.
The application of hydrogen peroxide has been replaced with the use of saline wash, substances such as Debrisan and Intrasite Gel for the removal of necrotic tissue, and the application of hydrogel dressings such as Granuflex. Varidase is a desloughing agent with wound cleansing properties, and contains streptokinase and streptodornase (Thomas, 1990b).
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Howard Gilbert
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